Research Results in Pharmacology 2(1): 42-45, doi: 10.18413/2313-8971-2016-2-1-42-45
STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION
expand article infoVladimir I. Yakushev, Nikolaj G. Filippenko, Irina V. Kizilova, Mikhail Viktorovich Korokin, Evgeniya Beskhmelnitsyna, Anna S. Litvinova
Open Access
Abstract
This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.
Keywords
endothelial dysfunction, a selective inhibitor of arginase II, nitric oxide, methionine, homocysteine.