Research Results in Pharmacology 2(1): 30-35, doi: 10.18413/2313-8971-2016-2-1-30-35
USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION
expand article infoEkaterina A. Shakhno, Tatyana Alexandrovna Savitskaya, Tatyana Grigoryevna Pokrovskaya, Vladimir I. Yakushev, Mikhail Vladimirovich Pokrovskii, Dmitry D. Grinshpan
Open Access
Abstract
For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environment. In animal experiments it was shown that granulirovannye the form of a combined preparation in dosages of 30 mg/kg, 70 mg/kg and 200 mg/kg exhibits a pronounced anti-hypertensive, endothelioprotecive and cardioprotective activity in a dosage of 200 mg/kg.
Keywords
L-arginine, L-NAME, water-soluble cellulose derivative, activated carbon, immobilized complex, endothelial dysfunction