Research Results in Pharmacology 2(1): 16-19, doi: 10.18413/2313-8971-2016-2-1-16-19
ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA
expand article infoVladimir Ya. Provotorov, Mikhail Viktorovich Korokin, Mikhail Vladimirovich Pokrovskii, Sergej V. Povetkin, Galina A. Lazareva, Aleksandr A. Stepchenko, Natalya A. Bystrova
Open Access
Abstract
The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studied. It was shown that the combined use of vitamin B6 and folic acid allows on the background of a significant reduction in homocysteine concentrations normalizing the endothelial dysfunction coefficient and the parameters of maximum left ventricular pressure in response to intravenous administration of adrenaline. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.
Keywords
endothelial dysfunction, folic acid, vitamin B6, hyperhomocysteinemia.