Research Results in Pharmacology 1(1): 3-8, doi: 10.18413/2500-235X-2015-1-4-4-8
CONCOMITANT USE OF STATINS AND S-(2-BORON-ETHYL)-L-CYSTEINE ARGINASE INHIBITOR TO CORRECT ENDOTOXIN-INDUCED ENDOTHELIAL DYSFUNCTION
expand article infoTatiana Alekseevna Denisyuk, Serghei A. Demchenko, Karen V. Saroyan
Open Access
Abstract
The concomitant use of non-selective S-(2-boron-ethyl)-L-cysteine (BEC) arginase inhibitor with simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of endotoxin-induced disorder modeling by Staphylococcus aureus (strain 13407) injection under the skin – 60 billions of microbial bodies – exhibits an endothelium- and cardio-protective action which is evident as endothelial dysfunction factor (EDF) increase prevention, adrenoreactivity, maintenance of myocardial reserve, and normalization of biochemical markers (total NO, expression of eNOS, C-reactive protein, IL-6, tumor necrosis factor). However, the concomitant therapy has shown no additive action of medications.
Keywords
endothelial dysfunction, statins, S-(2-boron-ethyl)-L-cysteine, simvastatin, atorvastatin, rosuvastatin, endotoxin.